abstract：BACKGROUND:Polo-like kinase 1 (Plk1), as a characteristic regulator in meiosis, organizes multiple biological events of cell division. Although Plk1 has been implicated in various functions in somatic cell mitotic processes, considerably less is known regarding its function during the transition from metaphase I (MI) t...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zhang Z,Chen C,Ma L,Yu Q,Li S,Abbasi B,Yang J,Rui R,Ju S

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) international body mass index (BMI) cut-off points defining pre-pregnancy BMI categories in the Institute of Medicine (IOM) guidelines are not directly applicable to Asians. We aimed to define the optimal gestational weight gain (GWG) for the Korean population based on Asi...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Choi SK,Lee G,Kim YH,Park IY,Ko HS,Shin JC

更新日期：2017-08-22 00:00:00

abstract：BACKGROUND:Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such a...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang JY,Yu PH,Li YC,Kuo PL

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:The full maturational capability of mammalian oocytes is accompanied by nuclear and cytoplasmic modifications, which are associated with proliferation and differentiation of surrounding cumulus cells. These events are regulated on molecular level by the expression of target genes involved in signal transduct...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Budna J,Rybska M,Ciesiółka S,Bryja A,Borys S,Kranc W,Wojtanowicz-Markiewicz K,Jeseta M,Sumelka E,Bukowska D,Antosik P,Brüssow KP,Bruska M,Nowicki M,Zabel M,Kempisty B

更新日期：2017-06-02 00:00:00

abstract：BACKGROUND:The aim of this study was to compare pregnancy rates in patients undergoing IVF/ICSI with embryo transfer after 4 and 5 days of culture in a closed incubation system with integrated time-lapse imaging. METHODS:Out of n = 2207 in vitro fertilization (IVF)/ intracytoplasmic sperm injection (ICSI) cycles perfo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Holschbach V,Weigert J,Dietrich JE,Roesner S,Montag M,Strowitzki T,Toth B

更新日期：2017-05-08 00:00:00

abstract：BACKGROUND:Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Han X,He Y,Zeng G,Wang Y,Sun W,Liu J,Sun Y,Yu J

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Premutation range CGGn repeats of the FMR1 gene denote risk toward primary ovarian insufficiency (POI), also called premature ovarian failure (POF). This prospective cohort study was undertaken to determine if X-chromosome inactivation skew (sXCI) is associated with variations in FMR1 CGG repeat length and, ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Barad DH,Darmon S,Weghofer A,Latham GJ,Filipovic-Sadic,Wang Q,Kushnir VA,Albertini DF,Gleicher N

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:The synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex with the redox partner NADPH-cytochrome P450 oxidoreductase (CPR) fo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Dos Santos AC,Conley AJ,de Oliveira MF,Oliveira GB,Viana DC,Assis Neto AC

更新日期：2017-04-24 00:00:00

abstract：BACKGROUND:Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) and Nur77 are novel regulators of decidualization. We ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Huang C,Jiang Y,Zhou J,Yan Q,Jiang R,Cheng X,Xing J,Ding L,Sun J,Yan G,Sun H

更新日期：2017-03-31 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 9-18% of women in reproductive age that causes hyperandrogenism and infertility due to dysfunctional follicular maturation and anovulation. The etiology of PCOS is still poorly known, and information from experimental animal models may help imp...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Paixão L,Ramos RB,Lavarda A,Morsh DM,Spritzer PM

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Endometriosis has been shown to be associated with second- to third-trimester pregnancy complications such as preterm birth and placenta previa, but the evidence is inconsistent. We hypothesized that endometriosis severity might affect these inconsistent results. Therefore we aimed to conduct a retrospective...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Fujii T,Wada-Hiraike O,Nagamatsu T,Harada M,Hirata T,Koga K,Fujii T,Osuga Y

更新日期：2016-11-03 00:00:00

abstract：BACKGROUND:ATF6α, one of the sensor proteins in the stress signaling pathway of the endoplasmic reticulum, is located in the membrane of the endoplasmic reticulum. To date, the physiological function of ATF6α in the process of embryo implantation has not been reported. METHODS:In this study, the expression pattern of ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Xiong Y,Li W,Lin P,Wang L,Wang N,Chen F,Li X,Wang A,Jin Y

更新日期：2016-10-07 00:00:00

abstract：BACKGROUND:In Spanish public hospital Reproduction Units it is very problematic to perform programmed intrauterine insemination (IUI) on weekends, if indicated. Small previous pilot studies suggest that using a GnRH antagonist to avoid an LH weekend surge would allow to perform IUI on the following Monday, not impairin...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gobernado J,Alvarez-Colomo C,Rodriguez-Tabernero L,Barrero L,Fernández-Gómez JM,Schneider J

更新日期：2016-09-02 00:00:00

abstract：BACKGROUND:Human uterine leiomyoma (fibroids; LYO) are the most common benign neoplasms in reproductive-aged women. Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression. The relat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Guan Y,Guo L,Zukerberg L,Rueda BR,Styer AK

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:In several species, considerably higher levels of estradiol-17 (E2) are synthesized in the CL. E2 has been suggested to participate in the regulation of luteal steroidogenesis and luteal cell morphology. In pregnant rats, several experiments have been carried out to examine the effects of inhibition of lutea...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Tripathy S,Asaithambi K,Jayaram P,Medhamurthy R

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Oocyte donation is a medical technique used principally for woman with ovarian failure. Optimizing donor recruitment is essential to obtain the best results with this technique. Understanding how donor parameters influence outcome for the recipients is fundamental. The aim of this study was to determine whet...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Delesalle AS,Robin G,Thomas-Desrousseaux P,Dewailly D,Catteau-Jonard S

更新日期：2016-01-19 00:00:00

abstract：BACKGROUND:Patients hoping to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hyperplasia (AEH) . Such treatment generally involves frequent intrauterine operations, including dilati...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Inoue O,Hamatani T,Susumu N,Yamagami W,Ogawa S,Takemoto T,Hirasawa A,Banno K,Kuji N,Tanaka M,Aoki D

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:Endometriosis is a well-known cause of infertility, and the anti-Mullerian hormone (AMH) is an accepted biomarker of ovarian reserve and response to artificial reproductive technology procedures. The present study was a prospective analysis of age-dependent AMH serum concentration in women with bilateral and...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Nieweglowska D,Hajdyla-Banas I,Pitynski K,Banas T,Grabowska O,Juszczyk G,Ludwin A,Jach R

更新日期：2015-11-24 00:00:00

abstract：BACKGROUND:Intracytoplasmic morphologically selected sperm injection (IMSI) is still proposed and employed in the clinical practice to improve the reproductive outcome in infertile couples scheduled for conventional intracytoplasmic sperm injection (cICSI). The aim of the current randomized controlled trial (RCT) was t...

journal_title：Reproductive biology and endocrinology : RB&E

authors： La Sala GB,Nicoli A,Fornaciari E,Falbo A,Rondini I,Morini D,Valli B,Villani MT,Palomba S

更新日期：2015-08-27 00:00:00

abstract：BACKGROUND:The placenta is an essential organ that provides nutrients and oxygen to the developing fetus and removes toxic waste products from the fetal circulation. Maintaining placental blood osmotic pressure and blood flow is crucial for viable offspring. The renin-angiotensin system (RAS) in the placenta is a key p...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Vaswani K,Chan HW,Verma P,Dekker Nitert M,Peiris HN,Wood-Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-08-12 00:00:00

abstract：BACKGROUND:Meta-analysis revealed that embryo placement 20 mm from the fundal endometrial surface resulted in higher pregnancy rate, ongoing pregnancy rate, and live birth rate compared with placement 10 mm from the fundal endometrial surface. Pregnancy and implantation rates according to relative position were higher ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Kwon H,Choi DH,Kim EK

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:The syncytialization of cytotrophoblast cells to syncytiotrophoblast is central to human placental transport and hormone production. Many techniques for in vitro study of this process have been proposed and new investigators to the field may find the literature in the field daunting. Here, we present a strai...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Li L,Schust DJ

更新日期：2015-07-09 00:00:00

abstract：BACKGROUND:The objective was to determine the effect of prepartum diets supplemented with rolled canola seed (high in oleic acid) or sunflower seed (high in linoleic acid) on luteinizing hormone (LH) pulsatility and gonadotropin releasing hormone (GnRH)-induced LH release during early postpartum. METHODS:Thirty-one pr...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Salehi R,Colazo MG,Oba M,Ambrose DJ

更新日期：2015-07-03 00:00:00

abstract：BACKGROUND:Relaxin levels in seminal plasma have been associated with positive effects on sperm motility and quality, and thus having potential roles in male fertility. However, the origin of seminal relaxin, within the male reproductive tract, and the moment of its release in the vicinity of spermatozoa remain unclear...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Feugang JM,Greene JM,Sanchez-Rodríguez HL,Stokes JV,Crenshaw MA,Willard ST,Ryan PL

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:Low functional ovarian reserve (LFOR) has been associated with hypoandrogenemia and increased embryo aneuploidy, while androgen supplementation has been reported to improve aneuploidy rates. We, therefore, assessed whether in infertile women undergoing in vitro fertilization (IVF) androgen concentrations are...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,McCulloh DH,Kushnir VA,Ganguly N,Barad DH,Goldman KN,Kushnir MM,Albertini DF,Grifo JA

更新日期：2015-05-06 00:00:00

abstract：BACKGROUND:Relaxin is detected in seminal plasma of many species and its association with sperm motility may be beneficial in some aspects of assisted reproduction. Here, we immunolocalized relaxin receptors and investigated the effects of exogenous relaxin on motility characteristics, viability, and cAMP content of bo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Feugang JM,Rodríguez-Muñoz JC,Dillard DS,Crenshaw MA,Willard ST,Ryan PL

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:The transformation of endometrium into decidua is essential for normal implantation of the blastocyst. However, the post-transcriptional regulation and the miRNAs involved in decidualization remain poorly understood. Here, we examined microRNA-181a (miR-181a) expression in decidualized human endometrial stro...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Zhang Q,Zhang H,Jiang Y,Xue B,Diao Z,Ding L,Zhen X,Sun H,Yan G,Hu Y

更新日期：2015-03-26 00:00:00

abstract：BACKGROUND:In animals, low levels of vitamin D are associated with estrus cycle disturbances, but there are virtually no human data. We examined the association of 25-hydroxyvitamin D (25(OH)D) (a biomarker for vitamin D status) with menstrual cycle characteristics. METHODS:Women aged 35-44 were randomly selected from...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Jukic AM,Steiner AZ,Baird DD

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:With infertility populations rapidly aging, treatments improving pregnancy chances assume increasing clinical importance. Dehydroepiandrosterone (DHEA) has been reported to improve pregnancy rates and lower miscarriage rates in women with diminished ovarian function. This study was planned to evaluate whethe...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Tartagni M,Cicinelli MV,Baldini D,Tartagni MV,Alrasheed H,DeSalvia MA,Loverro G,Montagnani M

更新日期：2015-03-09 00:00:00

abstract：BACKGROUND:The physiological state of the dominant follicle is important as it may be linked to the competence of the oocyte within. The objective of this study was to analyze, by transcriptomic analysis, the changes occurring in granulosa cells from dominant follicles at different phases of follicular growth. METHODS...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Girard A,Dufort I,Douville G,Sirard MA

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:Di(2-ethylhexyl) phthalate (DEHP) exposure reduces embryo implantations, increases embryonic loss, and decreases fetal body weights. However, whether it is associated with the alteration of luteal function remains unknown. Thus, our aim in this study was to explore the effect and mechanism of DEHP on luteal ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Guo M,Lai L,Zong T,Lin Y,Yang B,Zhang L,Li M,Kuang H

更新日期：2015-03-03 00:00:00

abstract：:Human embryonic stem cells (hESC) have emerged as attractive candidates for cell-based therapies that are capable of restoring lost cell and tissue function. These unique cells are able to self-renew indefinitely and have the capacity to differentiate in to all three germ layers (ectoderm, endoderm and mesoderm). Harn...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Desai N,Rambhia P,Gishto A

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:The cell membrane water channel protein, aquaporins (AQPs), regulate cellular water transport and cell volume and play a key role in water homeostasis. Recently, AQPs are considered as important players in the field of reproduction. In previous studies, we have established the presence of AQP1 and 5 in porci...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Skowronska A,Młotkowska P,Wojciechowicz B,Okrasa S,Nielsen S,Skowronski MT

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:Endocannabinoids (ECs) are important contributors to implantation and decidualization and are suppressed in early pregnancy. Elevated levels of anandamide (AEA), the endogenous ligand for the CB1 and CB2 receptors (R), interfere with receptivity of the blastocyst. Ang-(1-7) is down-regulated in the implantat...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Brosnihan KB,Pulgar VM,Gallagher PE,Neves LA,Yamaleyeva LM

更新日期：2015-01-17 00:00:00

abstract：BACKGROUND:Embryo selection has been an integral feature of in vitro fertilization (IVF) almost since its inception. Since the advent of extended blastocyst stage embryo culture, and especially with increasing popularity of elective single embryo transfer (eSET), the concept of embryo selection has increasingly become ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Gleicher N,Kushnir VA,Barad DH

更新日期：2015-01-11 00:00:00

abstract：BACKGROUND:Density gradient is the preferred technique for sperm processing for ART. However, no study has examined sperm quality using different processing media simultaneously and under identical conditions. Therefore, we evaluated semen quality following sperm preparation by three commonly used commercially availabl...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Malvezzi H,Sharma R,Agarwal A,Abuzenadah AM,Abu-Elmagd M

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Flow cytometric sorting can be used to separate sperm based on sex chromosome content. Differential fluorescence emitted by stained X- vs. Y-chromosome-bearing sperm enables sorting and collection of samples enriched in either X- or Y-bearing sperm for use to influence the likelihood that the offspring will ...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Karabinus DS,Marazzo DP,Stern HJ,Potter DA,Opanga CI,Cole ML,Johnson LA,Schulman JD

更新日期：2014-11-24 00:00:00

abstract：:Gonadotropins extracted from the urine of post-menopausal women have traditionally been used to stimulate folliculogenesis in the treatment of infertility and in assisted reproductive technology (ART). Products, such as human menopausal gonadotropin (hMG), consist not only of a mixture of the hormones, follicle-stimul...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Ezcurra D,Humaidan P

更新日期：2014-10-03 00:00:00

abstract：BACKGROUND:The overall prevalence of infertility was estimated to be 3.5-16.7% in developing countries and 6.9-9.3% in developed countries. Furthermore, according to reports from some regions of sub-Saharan Africa, the prevalence rate is 30-40%. The consequences of infertility and how it affects the lives of women in p...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Bahamondes L,Makuch MY

更新日期：2014-09-08 00:00:00

abstract：BACKGROUND:Overweight and obese women have been shown to have an increased risk of recurrent miscarriage as well as other adverse reproductive outcomes, but it is yet unclear whether this is due to an effect on the endometrium, embryo or both. The current study employs proteomic analysis to examine for a potential endo...

journal_title：Reproductive biology and endocrinology : RB&E

authors： Metwally M,Preece R,Thomas J,Ledger W,Li TC

更新日期：2014-08-05 00:00:00